Hotels in Florence: 39 chain hotels with addresses

39 hotels in Florence, United States from Choice Hotels, Hilton, Wyndham Hotels & Resorts, Marriott International and more, with addresses, phone numbers…

FlightGPT lists 39 chain hotels in Florence, United States, from 8 hotel groups: Choice Hotels (10), Hilton (9), Wyndham Hotels & Resorts (7), Marriott International (6), IHG Hotels & Resorts (4), Best Western Hotels & Resorts (1) and others. For most of them the closest airport is Florence Regional Airport (FLO).

Built from each chain's own hotel listing, latest collected 30 Oct, 2026.

Check live hotel rates in Florence

Choice Hotels (10)

Clarion Inn & Suites Florence - Darlington · 1819 West Lucas Street, Florence
Comfort Inn & Suites Florence Center Area · 527 Woody Jones Blvd., Florence
Comfort Suites Florence I-95 · 2120 West Lucas Street, Florence
Econo Lodge Florence - Darlington · 1920 West Lucas Street, Florence
MainStay Suites Florence - Darlington · 1819 West Lucas Street, Florence
Park Inn by Radisson Florence, SC · 1729 Mandeville Road, Florence
Quality Inn & Suites Florence Civic Center · 150 Dunbarton Drive, Florence
Rodeway Inn Florence Downtown · 415 S. Irby St., Florence
Sleep Inn Florence North · 1833 Florence Park Dr., Florence
Suburban Studios Florence I-95 · 1914 West Lucas Street, Florence

Hilton (9)

Hampton Inn & Suites Florence Center · 3000 West Radio Drive, Florence
Hampton Inn & Suites Florence-North-I-95 · 1735 Stokes Road, Florence
Hilton Garden Inn Florence · 2671 Hospitality Boulevard, Florence
Hilton Garden Inn Florence North I 95 · 2111 Florence Harllee Blvd, Florence
Home2 Suites by Hilton Florence, SC · 900 Woody Jones Boulevard, Florence
Homewood Suites by Hilton Florence · 3450 W Radio Drive, Florence
Hotel Florence, Tapestry Collection by Hilton · 126 W. Evans Street, Florence
Spark by Hilton Florence North I-95, SC · 1739 Mandeville Rd, Florence
Tru by Hilton Florence I-95 · 2140 West Lucas Street, Florence

Wyndham Hotels & Resorts (7)

Days Inn by Wyndham Florence Near Civic Center · 140 Dunbarton Dr, Florence
Days Inn by Wyndham Florence/I-95 North · 2111 West Lucas St, Florence
Howard Johnson by Wyndham Florence · 2038 West Lucas Street, Florence
La Quinta Inn & Suites by Wyndham Florence · 2123 W Lucas St., Florence
Microtel Inn & Suites by Wyndham Florence · 1912 Enterprise Drive, Florence
Super 8 by Wyndham Florence · 1832 1/2 Lucas Street, Florence
Super 8 by Wyndham Florence SC I-95 North / Hwy 76 · 3783 W. Palmetto St, Florence

Marriott International (6)

Aloft by Marriott Florence · 820 Woody Jones Boulevard, Florence
Courtyard by Marriott Florence · 2680 Hospitality Blvd., Florence
Fairfield by Marriott Inn & Suites Florence I-20 · 501 Woody Jones Boulevard, Florence
Residence Inn by Marriott Florence · 2660 Hospitality Boulevard, Florence
SpringHill Suites by Marriott Florence · 2670 Hospitality Boulevard, Florence
TownePlace Suites by Marriott Florence · 2650 Hospitality Boulevard, Florence

IHG Hotels & Resorts (4)

avid hotels Florence North · 1728 Mandeville Rd, Florence
Holiday Inn Express & Suites Florence I-95 @ Hwy 327 · 2101 Florence Harllee Blvd, Hwy 327
Holiday Inn Express & Suites Florence I-95 & I-20 Civic Ctr · 3440 West Radio Drive, Florence
Staybridge Suites Florence - Center · 150 Westpark Drive, Florence

Best Western Hotels & Resorts (1)

Best Western Inn · 1808 W Lucas Street, Florence

Hyatt (1)

Hyatt Place Florence / Downtown · 100 East Evans Street, Florence

Red Roof (1)

Red Roof Inn Florence - Civic Center · 2690 David H McLeod Blvd, Florence

Frequently asked questions

How many chain hotels are there in Florence?

FlightGPT lists 39 hotels from the large hotel chains in Florence. Independent hotels are not included in this list.

Which hotel groups have hotels in Florence?

Choice Hotels (10), Hilton (9), Wyndham Hotels & Resorts (7), Marriott International (6), IHG Hotels & Resorts (4), Best Western Hotels & Resorts (1), Hyatt (1), Red Roof (1).

Which airport is closest to hotels in Florence?

Florence Regional Airport (FLO) is the closest airport with scheduled flights for 32 of the 39 listed hotels.

All cities with chain hotels in United States

Sources: Each chain's own hotel listing, collected 30 Oct, 2026 via All The Places (CC0); city data from GeoNames; airport positions from OurAirports. FlightGPT does not add details a hotel chain doesn't publish. Rates and availability are checked live when you search.